What's Hot in Complement 2020-2021

Dalakas, M. C., Alexopoulos, H., & Spaeth, P. J. (2020). Complement in neurological disorders and emerging complement-targeted therapeutics. In Nature Reviews Neurology (Vol. 16, Issue 11, pp. 601–617). Nature Research. https://doi.org/10.1038/s41582-020-0400-0

Goetzl, E. J., Srihari, V. H., Guloksuz, S., Ferrara, M., Tek, C., & Heninger, G. R. (2020). Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis. Translational Psychiatry 10 (1). https://doi.org/10.1038/s41398-020-01046-3

Kamitaki, N., Sekar, A., Handsaker, R. E., de Rivera, H., Tooley, K., Morris, D. L., Taylor, K. E., Whelan, C. W., Tombleson, P., Loohuis, L. M. O., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., … Spencer, C. C. A. (2020). Complement genes contribute sex-biased vulnerability in diverse disorders. Nature https://doi.org/10.1038/s41586-020-2277

Kopczynska, M., Zelek, W., Touchard, S., Gaughran, F., Di Forti, M., Mondelli, V., Murray, R., O’Donovan, M. C., Morgan, B. P. (2019). Complement system biomarkers in first episode psychosis. Schizophrenia Research 204,16–22. https://doi.org/10.1016/j.schres.2017.12.012

Magdalon, J., Mansur, F., Teles e Silva, A. L., de Goes, V. A., Reiner, O.,  Sertié, A. L. (2020). Complement System in Brain Architecture and Neurodevelopmental Disorders. In Frontiers in Neuroscience (Vol. 14). Frontiers Media S.A. https://doi.org/10.3389/fnins.2020.00023

Mongan, D., Sabherwal, S., Susai, S. R., Föcking, M., Cannon, M., Cotter, D. R. (2020). Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies. In Schizophrenia Research (Vol. 222, pp. 58–72). Elsevier B.V. https://doi.org/10.1016/j.schres.2020.05.036

Purves-Tyson, T. D., Robinson, K., Brown, A. M., Boerrigter, D., Cai, H. Q., Weissleder, C., Owens, S. J., Rothmond, D. A., & Shannon Weickert, C. (2020). Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia. Frontiers in Immunology 11 https://doi.org/10.3389/fimmu.2020.02002

Sellgren, C. M., Gracias, J., Watmuff, B., Biag, J. D., Thanos, J. M., Whittredge, P. B., Fu, T., Worringer, K., Brown, H. E., Wang, J., Kaykas, A., Karmacharya, R., Goold, C. P., Sheridan, S. D. Perlis, R. H. (2019). Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nature Neuroscience 22 (3), 374–385. https://doi.org/10.1038/s41593-018-0334-7

Wallace, J., Lord, J., Dissing-Olesen, L., Stevens, B., Murthy, V. N. (2020). Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb. ELife. https://doi.org/10.7554/eLife.50531

Woo, J. J., Pouget, J. G., Zai, C. C., Kennedy, J. L. (2020). The complement system in schizophrenia: where are we now and what’s next? In Molecular Psychiatry (Vol. 25, Issue 1, pp. 114–130). Springer Nature. https://doi.org/10.1038/s41380-019-0479-0