Cascade Biotechnology INC | Complement Therapeutics; novel approach to CNS/PNS disease management using the innate complement system.

Neurological Diseases

Amyotrophic Lateral Sclerosis (ALS)-Autoimmune

  • Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no available therapy. Components of the innate immune system are activated in the spinal cord and central nervous system of ALS patients. 

  • Studies in the SOD1G93A mouse show deposition of C1q and C3/C3b at the motor end-plate before neurological symptoms are apparent, suggesting that complement activation precedes neurodegeneration in this model. 

  • Analyzing post-mortem tissue of ALS donors may lead to a better understanding of the complement system’s role  and it’s activation at the motor end-plate in human ALS. (Bahia , Idrissi , Bosch , Ramaglia , Aronica , Baas  Troost D (2016) Complement activation at the motor end-plates in amyotrophic lateral sclerosis. J Neuroinflammation. Apr 7;13(1):72. doi: 10.1186/s12974-016-0538-2).