Complement resolves immunological problems, yet over-activation may lead to these diseases:

• Cognitive: Alzheimer’s Disease (AD), Prodromal Schizophrenia (SZ)

• Neurological & autoimmune: Myasthenia Gravis (MG), Multiple Sclerosis (MS), Neuromyelitis Optica (NMO)

• Cancers: Cutaneous Squamous Cell Carcinoma (cSCC)

• Retinal: Age-related macular degeneration (AMD)

• Coronary: Cardiac and Myocardial Ischemia (MI)

• Renal: atypical hemolytic uremic syndrome (aHUS)

• Blood: Paroxysmal nocturnal hemoglobinuria (PNH)